TECHNOLOGY LICENSING OPPORTUNITY: Bacterial Lipid Nanodiscs Platform

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Version Current Record 2026-06-15 14:18:54 Pre-Award Solicitation Details Classification Description Contact Information Attachments/Links TECHNOLOGY LICENSING OPPORTUNITY: Bacterial Lipid Nanodiscs Platform

Active

Opportunity TECHNOLOGY LICENSING OPPORTUNITY: Bacterial Lipid Nanodiscs Platform

Active

Notice ID S-191192

Related Notice (blank)

Contract Opportunity Type Special Notice

Contract Line Item Number (blank)

Inactive Dates Jun 15, 2027

Inactive Policy Manual

Response Date Dec 15, 2026 5:00 PM MST

Published Date Jun 15, 2026 12:20 PM MDT

Department/Ind. Agency ENERGY, DEPARTMENT OF

Sub-tier ENERGY, DEPARTMENT OF

Office TRIAD - DOE CONTRACTOR

Original Set Aside No Set aside used

Product Service Code AJ11 - GENERAL SCIENCE AND TECHNOLOGY R&D SERVICES; GENERAL SCIENCE AND TECHNOLOGY; BASIC RESEARCH

NAICS Code 541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance (blank)

Initiative None

The Bacterial Lipid Nanodiscs Platform developed by Los Alamos National Laboratory provides a new way to study entire bacterial membranes in a controlled, nanoscale format derived directly from native lipid extracts. Researchers gain access to membrane components that typically remain difficult to isolate, stabilize or analyze, enabling more accurate evaluation of immunogenic lipids and membrane‑associated targets. The platform offers a safer alternative to handling live high‑risk pathogens while preserving the biological context that drives meaningful insights for vaccine design and antimicrobial discovery such as therapeutic antibodies to conserved lipids on bacterial membranes.

How it Works

The Bacterial Lipid NanodiscsPlatform creates uniform nanoscale discs from total lipid extracts harvested from bacterial membranes. Membrane scaffold protein MSP1D1 encases the lipid mixture and forms a stable disc roughly 10 nanometers wide. The resulting particles retain the full complement of native bacterial lipids, arranged in a membrane‑like environment that supports realistic biological interactions without requiring synthetic lipids or live cells.

Technical Description

The method adapts established nanodisc assembly techniques to incorporate entire bacterial lipid extracts rather than defined synthetic lipid mixtures. Total lipids from a pathogen are solubilized, combined with MSP1D1 and dialyzed under controlled conditions to allow the scaffold protein to form a discoidal structure around the heterogeneous lipid population. The…

Topic areas: General and Cross-cutting R&D, Advanced Manufacturing and Industry, Life Sciences and Health.

Funding amount

This contract provides Varies in funding.

Deadline

Applications are due Dec 15, 2026. Confirm the exact closing time on the official program page before applying.

Who can apply

This opportunity is open to the following applicant types:

• SME
• MidCaps
• Large Company
• Startups
• University
• Research Organization
• NGOs
• Public Authorities

Eligibility

No Set aside used

Agency

TECHNOLOGY LICENSING OPPORTUNITY: Bacterial Lipid Nanodiscs Platform is administered by Energy, Department Of (ED), listed via SAM.gov.