Single-Cell Analysis of Inflammation

About this funding opportunity

This RFA closed on November 19, 2019

SCIENCE GRANT RESOURCES PAGE Single-Cell Analysis of Inflammation

The Chan Zuckerberg Initiative invites applications for two-year collaborative pilot projects focused on the role of inflammation in maintaining health and triggering disease. CZI will accept applications from teams of two to three researchers with distinct expertise. Applicants can request up to $175,000 in total costs per lab. Learn about our grantees and read our Medium post").

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For administrative and programmatic inquiries, technical assistance, or other questions pertaining to this RFA, please contact sciencegrants@chanzuckerberg.com. Key Dates

SEPTEMBER 17, 2019

Application portal opens

NOVEMBER 19, 2019

Applications due by 5:00 PM PT

MID-APRIL 2020

Earliest notification of decisions (subject to change)

MAY 1, 2020

Earliest start date of project (subject to change)

Award period and start date: Proposed projects should be two years in duration with a projected start date no earlier than May 1, 2020. Actual start date may vary. Opportunity

Overview

Inflammation is a feature of many diseases and a cross-cutting area of biomedicine. Inflammation mediates the response to chronic and acute tissue injury and infection, driving homeostasis and tissue repair. It is also a driver of fibrosis, cardiovascular disease, inflammatory bowel disease, arthritis, neurodegeneration, adverse events associated with immunotherapies, and many other maladaptive processes. Mapping inflammation in diverse tissues is a path to understanding, diagnosing, and potentially treating many different diseases.

CZI seeks applications aimed toward identifying unifying principles that underlie tissue homeostasis and inflammation at the single cell level. Our goal is to stimulate collaborations across disciplines that will help define a new field. Successful applications will bring together researchers in different experimental, computational, or medical domains. They will address local cell properties and interactions in inflamed tissues and compare them to the properties and interactions of similar cells in healthy tissues. They will increase our understanding of the cell types that mediate inflammation, and their interactions in space and time. The two-year pilot grant period is intended to develop proof-of-concept for the experimental team and the approach, setting up future programs for detailed mechanistic investigations.

Structure of Research Teams

This program is aimed toward developing new teams, consisting of two or three principal investigators with different areas of expertise, who can advance interdisciplinary analysis of inflammation.

Scientific Scope

The long-term goal of this program is to address the mechanisms of inflammation at the cellular level, including its dynamics and resolution, its molecular drivers, and the effects of genetic and environmental risk factors on relevant cellular properties and interactions.

During this pilot phase, we especially seek proposals that support the development and integration of tools and resources for studying inflammation at the level of local cells and tissues, including volumetric imaging, image-based transcriptomics and proteomics, single-cell transcriptomics, organoids and other tissue models, and computation.

This funding opportunity is explicitly aimed at the cell and tissue level. It is not intended to support clinical trials, drug development, or whole-genome analysis.

Examples of Potential Collaborative Teams and Research Themes Biologist and Biologist Conduct parallel experiments on different tissues (e.g. transcriptomics) to identify common themes in inflammation (cells, signaling, genetics) Combine expertise in two relevant fields (e.g. immunology and neuroscience) to study inflammation at the intersection of those fields Technology Developer and Clinician or Biologist Develop, modify, or apply new…

Topic areas: Life Sciences and Health.

Funding amount

This grant provides Varies in funding.

Deadline

Applications are accepted on a rolling basis; there is no single fixed deadline.

Who can apply

This opportunity is open to the following applicant types:

• Not specified by the program.

Eligibility

The program did not publish a separate eligibility statement. See the official opportunity page for the full eligibility criteria.

Agency

Single-Cell Analysis of Inflammation is administered by Chan Zuckerberg Initiative (CZI), listed via Chan Zuckerberg Initiative.