PCORI Call for Proposals for HSII Implementation Projects -- 2026 (HSII Participants Only)

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Receiving Invited Applications PCORI Call for Proposals for HSII Implementation Projects -- 2026 (HSII Participants Only)

Health Systems Implementation Initiative (HSII)

One-time Opportunity Key Dates CFP Open

April 1, 2026 Letter of Intent (LOI) Deadline

April 28, 2026; 5 pm (ET) LOI Status Notification

June 2, 2026 Application Deadline

Sept. 1, 2026; 5 pm (ET)

Apply Here")

The intent of this Call for Proposals (CFP) for Health Systems Implementation Initiative (HSII) Implementation Projects is to provide an opportunity for HSII Participants to propose projects that promote the uptake of specific evidence from PCORI-funded patient-centered comparative clinical effectiveness research within their healthcare delivery settings. Each HSII Participant may propose one project in response to this CFP. Project Types

Applicants will have the opportunity to propose one of two project types: HSII Implementation Projects. These projects will have the goal of broadly integrating evidence into care delivery within the health system’s settings. HSII Implementation Projects should accomplish the desired practice change in ways that are sustainable within the HSII Participant delivery setting and scalable within their system, as relevant. Projects will include rigorous program evaluation that documents the execution of implementation activities, as well as the impact on health and healthcare outcomes. HSII Pilot Projects. These projects will have the goal of developing and/or refining a proposed implementation approach, i.e., a bundle of implementation strategies, and then piloting the use of the approach by integrating use of the evidence on a small scale. Project evaluation will be designed to demonstrate the feasibility and readiness of that approach, paving the way for a broader effort within the health system once the HSII Pilot Project is complete. Evidence Topics

The following topics will be offered in the CFP. Topic 5: Telepsychiatry Collaborative Care for Complex Psychiatric Disorders Topic 6: Family-Based Behavioral Treatment for Healthy Child Weight

This CFP will no longer offer the Antibiotics,…

Topic areas: Life Sciences and Health, Public Policy and Governance.

Funding amount

This grant provides Varies in funding.

Deadline

Applications are accepted on a rolling basis; there is no single fixed deadline.

Who can apply

This opportunity is open to the following applicant types:

• Not specified by the program.

Eligibility

The program did not publish a separate eligibility statement. See the official opportunity page for the full eligibility criteria.

Agency

PCORI Call for Proposals for HSII Implementation Projects -- 2026 (HSII Participants Only) is administered by Patient-Centered Outcomes Research Institute (PCORI), listed via Patient-Centered Outcomes Research Institute.