Mouse Phenotyping Request for Applications

About this funding opportunity

Search SFARI Home Funding Application Deadline

March 5, 2012 Notification of Award

June 1, 2012 Funding Expected to Begin

July 1, 2012 SFARI Grant Programs

sciencerfa@simonsfoundation.org Application Deadline

March 5, 2012 Notification of Award

June 1, 2012 Funding Expected to Begin

July 1, 2012 SFARI Grant Programs

sciencerfa@simonsfoundation.org

To maximize the ability to make direct comparisons among mouse models, this request for applications sought applications for systematic, rigorous and scalable analyses of behavioral phenotypes across multiple mouse models. The data produced in this effort was later made available.

SFARI has prioritized a small number of mouse models that have been generated with targeted genetic mutations based on strong human genetic evidence implicating them in autism spectrum disorders. These include mouse models of 16p11.2 chromosomal segment deletion, _Cntnap2_-/-and _Shank3b_-/-. Investigators are encouraged to use these models, but SFARI will consider others if compelling reasons based on human genetic data are specified in the application.

In recognition of other ongoing efforts in the research community, SFARI worked to increase availability of select mouse models at Jackson Laboratories. At the time, mouse models of the deletion of the human chromosomal segment 16p11.2 and its reciprocal duplication were available, but SFARI worked to facilitate the availability of additional autism models over time. Investigators were encouraged to use this resource and to contact the foundation for information about availability of additional models.

To achieve the goals of a comprehensive and systematically collected dataset, we expected investigators to test at least three genetic models in the same background strain (C57BL/6). In addition, investigators needed to analyze the behavior of one of the selected autism mouse models in a different genetic background, such as a hybrid background from two inbred strains. Application Deadline

March 5, 2012 Notification of Award

June 1, 2012 Funding Expected to Begin

July 1, 2012 SFARI Grant Programs

sciencerfa@simonsfoundation.org Instructions for submission

Applications must be completed electronically and submitted using forms provided at proposalCENTRAL. Please log in as an applicant, scroll to ‘Simons Foundation’ and click on the program. Contacts

Scientific inquiries: sciencerfa@simonsfoundation.org (646) 654-0066

Administrative inquiries: grants@simonsfoundation.org (646) 654-0066

proposalCENTRAL: pcsupport@altum.com (800) 875-2562 Application Deadline

March 5, 2012 Notification of Award

June 1, 2012 Funding Expected to Begin

July 1, 2012 SFARI Grant Programs

sciencerfa@simonsfoundation.org Comprehensive phenotyping of autism mouse models Awarded: 2012 Award Type: Targeted: Mouse Phenotyping Award #: 248429 Ted Abel, Ph.D. University of Iowa

The Simons Foundation uses an electronic grants submission process. All interested grant applicants must submit their applications online through proposalCENTRAL. Once you are logged into proposalCENTRAL: Navigate to the grant opportunities tab. Select Simons Foundation from the ’Filter by Grant Maker’ drop-down list. You will then see the list of current Simons Foundation grant opportunities.

proposal-central Go to proposalCENTRAL

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Topic areas: Life Sciences and Health.

Funding amount

This grant provides Varies in funding.

Deadline

Applications are accepted on a rolling basis; there is no single fixed deadline.

Who can apply

This opportunity is open to the following applicant types:

• Not specified by the program.

Eligibility

The program did not publish a separate eligibility statement. See the official opportunity page for the full eligibility criteria.

Agency

Mouse Phenotyping Request for Applications is administered by Simons Foundation (Simons), listed via Simons Foundation.