About this funding opportunity

This RFA closed on June 1, 2023

SCIENCE GRANT RESOURCES PAGE Measuring Metabolism Across Scales

The Chan Zuckerberg Initiative (CZI) seeks to support two-year collaborative research projects focused on measuring metabolism across organelles and cells. The ability to characterize temporally and spatially the broad molecular profiles, heterogeneity, and phenotypic diversity of organelles and cells and how they interact within and as systems are key to measuring human biology, understanding disease mechanisms, and finding treatments and cures. This Request for Applications (RFA) aims to accelerate innovative discoveries in metabolism and metabolic physiology in health and disease.

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For administrative and programmatic inquiries, technical assistance, or other questions pertaining to this RFA, please contact sciencegrants@chanzuckerberg.com. Key Dates

April 13, 2023

Application portal opens

June 1, 2023

Applications due by 5 p.m. Pacific Time (PT)

Mid-October 2023

Earliest notification of decisions (subject to change)

December 1, 2023

Expected start date (subject to change) Opportunity

Overview

To measure human biology, we need to understand the mysteries of the cell and how cells interact within and as systems. Metabolism is a complex and highly interconnected process, with many different pathways that feed into one another. It encompasses various biochemical processes, chemical reactions, and conversions that transform one form of energy into another, regulating the rate of nutrient uptake from the immediate environment to essentially maintain the living state of a cell or an organism. Metabolic physiology goes beyond studying metabolic pathways and requires consideration of dynamic processes that cross time and space scales. To clarify metabolism and its connection to diseases requires investigating how metabolism is integrated within molecules, organelles, cells, tissues, and organisms, further suggesting that multiple experimental and technological approaches are needed to measure metabolism in action. Mapping, measuring, and integrating metabolism across scales and systems is a path to understanding various facets of human physiology and addressing many common and rare diseases.

Scope and Project Specifications

The Chan Zuckerberg Initiative (CZI) seeks to support two-year collaborative research projects focused on measuring metabolism across organelles and cells. The ability to characterize temporally and spatially the broad molecular profiles, heterogeneity, and phenotypic diversity of organelles and cells and how they interact within and as systems are key to measuring human biology, understanding disease mechanisms, and finding treatments and cures. This Request for Applications (RFA) aims to accelerate innovative discoveries in metabolism and metabolic physiology in health and disease. Applications for two types of grants are welcome: Expanded Projects and Focused Projects. The maximum budgets for proposed projects are $500,000 total costs for _Expanded Projects_ and $250,000 total costs for _Focused Projects_. All project awards will be for a 24-month duration.

The long-term goal of this opportunity is to investigate the metabolic processes that maintain physiological homeostasis at the sub-cellular and cellular levels, and understand how and when these normal processes go awry. This two-year funding opportunity is explicitly aimed at addressing the mechanisms of metabolism, including its dynamics and resolution, molecular drivers, and the effects of genetic and environmental risk factors on relevant sub-cellular and cellular properties and interactions, and precisely mapping metabolic changes and states across various scales using a broad range of technologies. The projects should aim to use diverse experimental systems beyond immortalized cell lines to ensure the broadest possible insights into cellular and…

Topic areas: Life Sciences and Health, General and Cross-cutting R&D.

Funding amount

This grant provides Varies in funding.

Deadline

Applications are accepted on a rolling basis; there is no single fixed deadline.

Who can apply

This opportunity is open to the following applicant types:

Not specified by the program.

Eligibility

The program did not publish a separate eligibility statement. See the official opportunity page for the full eligibility criteria.

Agency

Measuring Metabolism Across Scales is administered by Chan Zuckerberg Initiative (CZI), listed via Chan Zuckerberg Initiative.