Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research PCORI Funding Announcement -- Cycle 2 2026

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Receiving Invited Applications Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research PCORI Funding Announcement -- Cycle 2 2026

Research

Cycle 2 2026 Key Dates PFA Open

April 1, 2026 Applicant Town Hall

View recording/slides Letter of Intent (LOI) Deadline

April 28, 2026; 5 pm (ET) LOI Status Notification

June 2, 2026 Application Deadline

Sept. 1, 2026; 5 pm (ET)

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With this PCORI Funding Announcement (PFA), PCORI aims to fund studies that address high-priority methodological gaps in patient-centered comparative clinical effectiveness research (CER).

For the Cycle 2 2026 Methods PFA, PCORI has identified the following areas that address important methodological gaps and lead to improvements in the strength and quality of evidence generated by CER studies: Methods To Support the Use of Patient-Centered Measurement in Patient-Centered CER (NEW) Methods To Support the Use of Real-World Data (RWD) in Multi-Site Patient-Centered CER (formerly Methods To Support Data Research Networks) Methods To Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Patient-Centered CER Methods To Improve Study Design in Patient-Centered CER

This funding announcement will accept applications with direct costs of up to $750,000 and up to three years in duration. What’s New for Cycle 2 2026 Introduction of the “Patient-Centered Measurement” programmatic priority, with topics including but not limited to: methods to develop, validate or apply standardized approaches for measuring patient-centered burdens and economic outcomes (PCBEOs); methods for harmonizing, linking, comparing or synthesizing data from different but related measurement instruments used across diverse settings, populations or time points; and methods for improving the measurement and analysis of contextual factors and mediators relevant to patient-centered outcomes. “Methods Related to Ethical and Human Subjects Protections Issues in Patient-Centered CER” will be retired as a stand-alone programmatic priority and integrated across the other priorities. PCORI maintains a strong…

Topic areas: Life Sciences and Health, Public Policy and Governance.

Funding amount

This grant provides Varies in funding.

Deadline

Applications are accepted on a rolling basis; there is no single fixed deadline.

Who can apply

This opportunity is open to the following applicant types:

• Not specified by the program.

Eligibility

The program did not publish a separate eligibility statement. See the official opportunity page for the full eligibility criteria.

Agency

Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research PCORI Funding Announcement -- Cycle 2 2026 is administered by Patient-Centered Outcomes Research Institute (PCORI), listed via Patient-Centered Outcomes Research Institute.