Improving Health Decision Making With Comparative Clinical Effectiveness Research: Retrospective Observational Studies Leveraging Existing Data Sources PCORI Funding Announcement -- Cycle 1 2026

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Applications Under Review Improving Health Decision Making With Comparative Clinical Effectiveness Research: Retrospective Observational Studies Leveraging Existing Data Sources PCORI Funding Announcement -- Cycle 1 2026

Research

Cycle 1 2026 Key Dates PFA Opened

Dec. 2, 2025 Applicant Town Hall

View recording/slides Letter of Intent (LOI) Deadline

Jan. 6, 2026; 5 pm (ET) LOI Status Notification

Feb. 3, 2026 Application Deadline

May. 5, 2026; 5 pm (ET)

Apply Here")

This PCORI Funding Announcement (PFA), Improving Health Decision Making with Comparative Clinical Effectiveness Research in Cancer, Pain, Substance Use, Maternal Morbidity and Mortality, Intellectual and Developmental Disabilities, Sensory Health, Metabolic and Endocrine Health, Mental and Behavioral Health and Rare Diseases: Retrospective Observational Studies Leveraging Existing Data Sources, seeks to fund well-designed, methodologically robust retrospective observational patient-centered comparative clinical effectiveness research (CER) studies that will produce timely, impactful and patient-centered results to inform healthcare decision making and improve health outcomes. Research Initiative Highlights

Retrospective observational studies can provide valuable data to address important questions for patients through timely evaluations of interventions in real-world settings. Studies leveraging established data sources can have meaningful roles in evaluating patient outcomes, as they allow for large and representative populations and provide an important complement to randomized controlled trials (RCTs) when RCTs are not practical or ethically acceptable. They also permit the study of clinical outcomes over a period of time longer than is typically feasible during the conduct of a clinical trial, allowing for observation of long-term impacts and unintended adverse events.

This PFA seeks to fund well-designed, retrospective observational studies that articulate a clear comparative effectiveness question by leveraging established data sources and infrastructure ready for patient-centered CER, including but not limited to…

Topic areas: Life Sciences and Health.

Funding amount

This grant provides Varies in funding.

Deadline

Applications are accepted on a rolling basis; there is no single fixed deadline.

Who can apply

This opportunity is open to the following applicant types:

• Not specified by the program.

Eligibility

The program did not publish a separate eligibility statement. See the official opportunity page for the full eligibility criteria.

Agency

Improving Health Decision Making With Comparative Clinical Effectiveness Research: Retrospective Observational Studies Leveraging Existing Data Sources PCORI Funding Announcement -- Cycle 1 2026 is administered by Patient-Centered Outcomes Research Institute (PCORI), listed via Patient-Centered Outcomes Research Institute.