Genomics of ASD: Pathways to Biological Convergence and Genetic Therapies, Request for Applications

About this funding opportunity

Search SFARI Home Funding Application Available

June 21, 2022 RFA Informational Session

July 5, 2022 Application Deadline

August 18, 2022 Award Notification

January 2023</span. Award Start Dates

March/April 2023 Scientific Inquiries

sciencerfa@simonsfoundation.org

646-654-0066 Administrative Inquiries

sfarigrants@simonsfoundation.org

646-654-0066 Simons Collections Inquiries

collections@sfari.org

646-654-0066 Application Available

June 21, 2022 RFA Informational Session

July 5, 2022 Application Deadline

August 18, 2022 Award Notification

January 2023</span. Award Start Dates

March/April 2023 Scientific Inquiries

sciencerfa@simonsfoundation.org

646-654-0066 Administrative Inquiries

sfarigrants@simonsfoundation.org

646-654-0066 Simons Collections Inquiries

collections@sfari.org

646-654-0066

Grants awarded through this request for applications (RFA) were intended to advance our understanding of the genetic basis of ASD and the molecular and cellular consequences of genetic risk, and to provide a foundation for the development of treatments for select genetically defined forms of the condition.

In recent years, the scientific community has identified more than 100 highly penetrant risk genes for ASD, owing in part to analyses of SFARI-sponsored cohorts such as SPARK, Simons Searchlight and the Simons Simplex Collection. Although important progress has been made in leveraging these genetic findings to better understand the biological underpinnings of ASD, much remains to be done.

In this RFA, we sought proposals in three different areas, with the common goal of identifying new possibilities for intervention. The first did so by identifying possible points of biological convergence among multiple genetic risk factors, which might then have suggested new therapeutic targets. The second continued SFARI-supported efforts to characterize the full range of functional variation in genes associated with neurodevelopmental disorders, again with an eye toward informing translational efforts. The third area focused on the development of genetically based therapies for select forms of ASD. We also encouraged applicants to familiarize themselves with resources that SFARI supports that may accelerate projects, such as our resource of iPS cells, mouse, rat and zebrafish models Application Available

June 21, 2022 RFA Informational Session

July 5, 2022 Application Deadline

August 18, 2022 Award Notification

January 2023</span. Award Start Dates

March/April 2023 Scientific Inquiries

sciencerfa@simonsfoundation.org

646-654-0066 Administrative Inquiries

sfarigrants@simonsfoundation.org

646-654-0066 Simons Collections Inquiries

collections@sfari.org

646-654-0066

The submission deadline is Thursday, August 18, 2022, 5:00 PM Eastern Time

Accessing the Application in proposalCENTRAL:

Prospective applicants must submit an application via proposalCENTRAL (pC). To start an application in pC, users must first log in to their pC account.

If You Need to Create a New Account in pC

To create a new account, go to proposalCENTRAL and click “Need an account?” under the “Applicant” login. Fill in the required fields, check the boxes to agree to pC’s “Terms of Service” and “Acceptable Use Policy” and then click “Save.” For the next steps, see the “If You Have an Existing Account in pC” section below.

If You Have an Existing Account in pC

For all users with a pC account, log in under the “Applicant or Awardee” login at proposalCENTRAL and select “Create New Proposal” or click on the “Grant Opportunities” tab. Scroll down to “Simons Foundation” and then click “Apply Now” for the “Simons Foundation Autism Research Initiative, 2022 Genomics of ASD: Pathways to Biological Convergence and Genetic Therapies” program in order to start the proposal and access the templates. After all sections are completed, you will be able to click on the “Submit” button.

Application Requirements and Submission Instructions

To submit an…

Topic areas: Life Sciences and Health.

Funding amount

This grant provides Varies in funding.

Deadline

Applications are accepted on a rolling basis; there is no single fixed deadline.

Who can apply

This opportunity is open to the following applicant types:

• Not specified by the program.

Eligibility

The program did not publish a separate eligibility statement. See the official opportunity page for the full eligibility criteria.

Agency

Genomics of ASD: Pathways to Biological Convergence and Genetic Therapies, Request for Applications is administered by Simons Foundation (Simons), listed via Simons Foundation.