Functional Screen of Autism-Associated Variants Request for Applications

About this funding opportunity

Search SFARI Home Funding Email Intent to Submit Proposal

March 27, 2015 Application Deadline

April 10, 2015 Notification of Award

July 1, 2015 Funding Expected to Begin

August 1, 2015 SFARI Grant Programs

sciencerfa@simonsfoundation.org Email Intent to Submit Proposal

March 27, 2015 Application Deadline

April 10, 2015 Notification of Award

July 1, 2015 Funding Expected to Begin

August 1, 2015 SFARI Grant Programs

sciencerfa@simonsfoundation.org

Grants awarded through this request for applications (RFA) were intended to advance our understanding of the genetic basis of autism, and in particular the potential role of missense and in-frame deletion variants in conferring risk.

Data to be analyzed under this RFA came in part from the exome sequencing of more than 2,500 families from the Simons Simplex Collection (SSC). Although much attention has been focused on _de novo_ mutations that clearly disable protein function, nonsense, splice-site, and frameshift mutations, the majority of what has been identified in the SSC falls into the category of missense variants of uncertain significance. The sequencing of additional large cohorts may help to distinguish pathogenic from benign variants on a purely statistical basis, but it is clear that these efforts will have to be complemented by screens to test such variants for functional relevance.

To this end, we sought proposals for the development and application of medium- or high-throughput screens to test for the functional effects of missense and in-frame deletion variants identified in the SSC and other autism collections. In addition to establishing the functional impact of _de novo_ missense mutations, one key goal was to compare the impact of such variants when inherited in individuals with autism vs. unaffected siblings (or those with autism vs. unrelated controls), to support a case for particular genes in autism susceptibility. Email Intent to Submit Proposal

March 27, 2015 Application Deadline

April 10, 2015 Notification of Award

July 1, 2015 Funding Expected to Begin

August 1, 2015 SFARI Grant Programs

sciencerfa@simonsfoundation.org

Instructions for submission

Applications must be completed electronically and submitted using forms provided at proposalCENTRAL. Please log in as an applicant, scroll to “Simons Foundation” and click on the program.

Contacts

Scientific inquiries: sciencerfa@simonsfoundation.org 646-654-0066 Administrative inquiries: grants@simonsfoundation.org 646-654-0066 SSC collection inquiries: collections@sfari.org 646-654-0066 proposalCENTRAL: pcsupport@altum.com 800-875-2562 Email Intent to Submit Proposal

March 27, 2015 Application Deadline

April 10, 2015 Notification of Award

July 1, 2015 Funding Expected to Begin

August 1, 2015 SFARI Grant Programs

sciencerfa@simonsfoundation.org Frequently Asked Questionsplus--large

Where do I submit my application proposal?plus--large

Applications are online and must be submitted online through proposalCENTRAL. New users first need to create a user account on proposalCENTRAL ( https://proposalcentral.altum.com/). For all users, log in and select “Create New Proposal” or click on the “Grant Opportunities” tab. Filter the Grant Maker by “Simons Foundation” and click on “Apply Now” next to the “Functional Screen of Autism-Associated Variants Request for Applications” program. Once all sections are complete and the attachments are uploaded, the “Submit” button will be activated.

How do I create a proposalCENTRAL user account?plus--large

Go to https://proposalcentral.altum.com/ and click “REGISTER” under “First Time Users.” Fill in the required fields, check the boxes to agree to proposalCENTRAL’s “Terms of Service and Acceptable Use Policy” and then click “Save.”

Is the Notice of Intent required to submit a full application? Is it the same as a Letter of Intent (LOI)?plus--large

No, the Notice of Intent is not required for application submission but we request that investigators who…

Topic areas: Life Sciences and Health.

Funding amount

This grant provides Varies in funding.

Deadline

Applications are accepted on a rolling basis; there is no single fixed deadline.

Who can apply

This opportunity is open to the following applicant types:

• Not specified by the program.

Eligibility

The program did not publish a separate eligibility statement. See the official opportunity page for the full eligibility criteria.

Agency

Functional Screen of Autism-Associated Variants Request for Applications is administered by Simons Foundation (Simons), listed via Simons Foundation.