Dynamic Imaging

About this funding opportunity

This RFA closed on August 23, 2022

SCIENCE GRANT RESOURCES PAGE Dynamic Imaging

The Chan Zuckerberg Initiative invites applications for challenge grants in the field of Dynamic Imaging. This Request for Applications (RFA) aims to advance technology directed at real-time visualization of biological processes at the level of cells and molecules.

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For administrative and programmatic inquiries, technical assistance, or other questions pertaining to this RFA, please contact sciencegrants@chanzuckerberg.com. Key Dates

June 21, 2022

Application portal opens

August 23, 2022

Applications due by 5 p.m. Pacific Time (PT)

January 2023

Earliest notification of decisions (subject to change)

March 1, 2023

Expected start date (subject to change)

Award period and start date: Awards will be 2.5 years (30 months) in duration with an expected start date of March 1, 2023.

IMPORTANT DOCUMENTS

Application Instructions")

Institutional Approval Form") Opportunity

Overview

The Chan Zuckerberg Initiative (CZI) invites applications in the field of dynamic imaging that will support the development of new tools or significant enhancements of existing tools to monitor biological processes in motion, across time, and across spatial scales. This grant program will provide 2.5-year challenge grants for projects with specified proof-of-concept milestones.

Scientific Scope

The long-term goal of this RFA, part of CZI’s Frontiers of Imaging effort, is to drive technology development aimed at measuring cellular and molecular processes in real time in intact, living systems. Priority will be given to proposals for methods developed for imaging in intact tissues or primary cells rather than immortalized cell lines. This opportunity is specifically aimed at technology development; it is not intended to support question-driven basic or translational research, clinical trials, or drug development. Preliminary data is encouraged but not required.

Examples of research themes include: Development, detection and/or tracking of multiple labels (e.g. multi-spectral Raman microscopy, hyperspectral imaging, tracking of multiple single particles labeled with different probes); Development of new dynamic reporters (e.g. reporters for protease activity, kinase activity, cellular ion concentration fluctuations, protein-protein interaction, organelle specific chemical labeling, mechanical or electrical forces); Development of correlative methods for temporal studies (e.g. correlative light and electron microscopy with a dynamic imaging component); Adaptation of static methods for dynamic imaging (e.g. improvements of liquid cell electron microscopy), and; Hardware, software, algorithm or biological probe development to obtain high-resolution dynamic measurements in deep tissue or in large volumes (e.g. 4D/5D imaging at cellular resolution in whole organs, 4D/5D cell microscopy at super-resolution).

We particularly encourage applications from: Researchers in disciplines outside of biomedicine who bring new technology, resources, or frameworks to studying cellular and molecular processes; Women, underrepresented minorities, and members of underserved populations; and Early-career investigators, defined as principal investigators who have been in an independent faculty role for less than six years at the time of application, i.e. starting their first position after August 2016

Desired Outcomes

Successful outcomes for this RFA could include: Development of new chemical probes, biological tools, and hardware for imaging molecular and cellular processes over time; Development of new protocols for imaging cellular and molecular processes over time, and; Development of new computational techniques and algorithms for detection, tracking, and analysis of targets of interest.

Collaboration and Open Science

CZI seeks investigators who will contribute to a collaborative…

Topic areas: Life Sciences and Health, Physical Sciences.

Funding amount

This grant provides Varies in funding.

Deadline

Applications are accepted on a rolling basis; there is no single fixed deadline.

Who can apply

This opportunity is open to the following applicant types:

• Not specified by the program.

Eligibility

The program did not publish a separate eligibility statement. See the official opportunity page for the full eligibility criteria.

Agency

Dynamic Imaging is administered by Chan Zuckerberg Initiative (CZI), listed via Chan Zuckerberg Initiative.