Collaborative Research Network 2025 Technical Track Opportunity

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Collaborative Research Network 2025 Technical Track Opportunity

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Funding Opportunities Save for later Collaborative Research Network 2025 Technical Track Opportunity

Objective:

The Aligning Science Across Parkinson’s (ASAP) Initiative invites applications from collaborative teams to join the ASAP Collaborative Research Network (CRN). For this cycle, applications within the Technical Track focused on supporting the development of novel tools that can be reliably produced and shared with the research community to accelerate validation and therapeutic R&D for emerging targets pursued or identified through ASAP discoveries will be considered. Objective: Generate, validate, and distribute preclinical reagents and/or models tailored to support critical research needs for at least 5 targets from a list of eligible targets, as outlined below. Funding Focus: Support tool-specific (not target-specific) projects that generate high-quality resources distributed via commercial mechanisms.

Approach: Teams must focus on a tool type (e.g., antibodies, viral vectors, mouse models) to ensure depth of expertise and quality of tools created for the panel of targets selected. Note that hypothesis-driven research is out of scope for this proposal. Once the tools have been developed and validated, there may be opportunities for additional funding support at that time to test target biology, but this is not the scope of the current call.

Key Components

Each Technical Track LOI application must include the following three components: (1) Tool Generation, (2) Tool Validation, and (3) Tool Distribution.

Tool Generation In Scope Generation of preclinical models to support _in vivo_ or _in vitro_ assessments of target or mutation function (e.g. genetically modified rodents or iPSCs, etc) of at least 5 targets from the ASAP prioritized list (see Eligible Targets section below) Generation of detection reagents to support improved measurement or visualization of the target or target activity (e.g. antibodies, nanobodies, probes) of at least 5 targets from the ASAP prioritized list (see Eligible Targets section below) Generation of modulation agents to understand the directionality of therapeutic benefit (e.g. viral vectors, compounds, antisense oligonucleotides, etc) of at least 5 targets from the ASAP prioritized list (see Eligible Targets section below) Out of Scope Projects to generate preclinical tools/models for targets outside the list provided by ASAP or projects that will not be generating _preclinical_ tools/models. Development of preclinical reagents or models incorporating third-party intellectual property that would prevent or significantly delay distribution. Development of preclinical reagents or models that duplicate existing tools or do not provide substantial benefit over alternatives available. Generation of therapeutic candidates or non-preclinical research tools that will remain undisclosed or inaccessible to the research community. Generation of target-agnostic devices (e.g. wearable devices, equipment, etc)

Tool Validation In Scope Validation of the tool in appropriate systems (e.g. knockout validation for antibodies, catalytically-dead control for tools towards kinase targets, etc). Characterization of the tool to inform conditions of use in PD research (e.g. application compatibility for antibodies, nigrostriatal system integrity in genetic rodent models, etc). Out of Scope Projects performing hypothesis-driven research rather than generating and validating novel preclinical tools/models. Therefore, in-depth mechanistic studies of the target biology, target pathway, or therapeutic potential of the target are out of scope.

Tool Distribution In Scope Research tools/models must be made available through the commercial repository or academic core represented by the Core/Repository Co-Investigator. This commercial repository or academic core must have a demonstrated history of…

Topic areas: Life Sciences and Health, General and Cross-cutting R&D.

Funding amount

This grant provides Varies in funding.

Deadline

Applications are accepted on a rolling basis; there is no single fixed deadline.

Who can apply

This opportunity is open to the following applicant types:

• Not specified by the program.

Eligibility

The program did not publish a separate eligibility statement. See the official opportunity page for the full eligibility criteria.

Agency

Collaborative Research Network 2025 Technical Track Opportunity is administered by Michael J. Fox Foundation (MJFF), listed via Michael J. Fox Foundation.