Broad Pragmatic Studies PCORI Funding Announcement -- Cycle 3 2026

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Upcoming Broad Pragmatic Studies PCORI Funding Announcement -- Cycle 3 2026

Research

Cycle 3 2026 Notice of Upcoming PCORI Funding Announcement Key Dates PFA Opens

Aug. 4, 2026 Applicant Town Hall

Aug. 13, 2026; 11:30 am (ET) Letter of Intent (LOI) Deadline

Sept. 9, 2026; 5 pm (ET) LOI Status Notification

Oct. 14, 2026 Application Deadline

Jan. 12, 2027; 5 pm (ET)

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA) on Aug. 4, 2026, seeking to fund high-impact, patient-centered comparative clinical effectiveness research (CER) projects. This preannouncement provides potential applicants additional time to identify collaborators; obtain patient and stakeholder input on potential studies; and develop responsive, high-quality applications. Research Initiative Highlights

Patient-centered CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences. Special Areas of Emphasis

For Cycle 3 2026, PCORI is particularly interested in submissions that address the following Special Areas of Emphasis (SAE) within the BPS funding opportunity. The purpose of identifying these SAEs is to encourage submissions to these areas, not to limit submissions to these topics. Applicants addressing one of the below SAEs should identify the area that is best associated with their research approach: Improving Mental Health and Substance Use Outcomes for Pregnant and Postpartum Populations: PCORI is interested in supporting high-quality, patient-centered comparative clinical…

Topic areas: Life Sciences and Health, Public Policy and Governance.

Funding amount

This grant provides Varies in funding.

Deadline

Applications are accepted on a rolling basis; there is no single fixed deadline.

Who can apply

This opportunity is open to the following applicant types:

• Not specified by the program.

Eligibility

The program did not publish a separate eligibility statement. See the official opportunity page for the full eligibility criteria.

Agency

Broad Pragmatic Studies PCORI Funding Announcement -- Cycle 3 2026 is administered by Patient-Centered Outcomes Research Institute (PCORI), listed via Patient-Centered Outcomes Research Institute.