Broad Pragmatic Studies PCORI Funding Announcement -- Cycle 2 2026

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Receiving Invited Applications Broad Pragmatic Studies PCORI Funding Announcement -- Cycle 2 2026

Research

Cycle 2 2026 Key Dates PFA Opens

April 1, 2026 Applicant Town Hall

View recording/slides Letter of Intent (LOI) Deadline

April 28, 2026; 5 pm (ET) LOI Status Notification

June 2, 2026 Application Deadline

Sept. 1, 2026; 5 pm (ET)

Apply Here")

This PCORI Funding Announcement (PFA) invites applications for high-impact patient-centered comparative clinical effectiveness research (CER) projects.

PCORI’s Research Project Agenda includes a set of Topic Themes that are included in this funding opportunity and further detailed below. Applicants have the option to choose up to three Topic Themes within the Research Project Agenda based on how their proposed research aligns with the themes. However, aligning with a Topic Theme is not required. The Topic Themes will assist PCORI in determining the optimal review pathway for the proposed research.

Applicants are strongly encouraged to propose individual or cluster randomized controlled trials; however, well-specified natural experiments and well-designed observational studies will also be considered. Proposed studies should include an overall sample size that will allow precision in the estimation of hypothesized effect sizes and, as appropriate, analysis of heterogeneity of treatment effect. Applicants are encouraged to pay special attention to issues of intervention implementation with an aim of facilitating widespread uptake of findings after completion of the study by utilizing hybrid effectiveness-implementation approaches. However, strict implementation or dissemination studies will not be considered responsive, nor will studies focused on the development of research methods. Applicants should propose well-justified and validated outcomes that are clinically meaningful and considered important by patients, and that can be impacted by the proposed interventions within the study duration.

Applicants should consider, as appropriate, the full range of clinical and patient-centered outcomes data relevant to patients and other stakeholders.…

Topic areas: Life Sciences and Health, General and Cross-cutting R&D.

Funding amount

This grant provides Varies in funding.

Deadline

Applications are accepted on a rolling basis; there is no single fixed deadline.

Who can apply

This opportunity is open to the following applicant types:

• Not specified by the program.

Eligibility

The program did not publish a separate eligibility statement. See the official opportunity page for the full eligibility criteria.

Agency

Broad Pragmatic Studies PCORI Funding Announcement -- Cycle 2 2026 is administered by Patient-Centered Outcomes Research Institute (PCORI), listed via Patient-Centered Outcomes Research Institute.