Addressing Substance Use PCORI Funding Announcement -- Cycle 3 2026

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Upcoming Addressing Substance Use PCORI Funding Announcement -- Cycle 3 2026

Research

Cycle 3 2026 Notice of Upcoming PCORI Funding Announcement Key Dates PFA Opens

Aug. 4, 2026 Applicant Town Hall

Aug. 18, 2026; noon (ET) Letter of Intent (LOI) Deadline

Sept. 9, 2026; 5 pm (ET) LOI Status Notification

Oct. 14, 2026 Application Deadline

Jan. 12, 2027; 5 pm (ET)

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a PCORI Funding Announcement (PFA) on Aug. 4, 2026, seeking to fund high-quality, patient-centered comparative clinical effectiveness research (CER) projects that focus on substance use/misuse and substance use disorders. This preannouncement provides potential applicants with additional time to identify collaborators, obtain patient and stakeholder input on potential studies and develop responsive, high-quality applications. Research Initiative Highlights

In 2024, 48.4 million people aged 12 or older in the United States were diagnosed with a substance use disorder, and approximately 58% reported current use of tobacco products, nicotine, alcohol or illicit drugs. However, an estimated 81% of those classified as needing substance use treatment did not receive it, resulting in significant morbidity, mortality and social and economic costs for individuals, families and communities. Recent data suggest more than 80,000 overdose deaths annually. These burdens are borne unevenly, creating variability in the delivery and outcomes of care. This Topical PFA will solicit applications focused on addressing substance use/misuse and substance use disorders.

For this PFA, "substance" refers to any psychoactive compound with the potential to cause health and social problems, including the development of a substance use disorder. Substances of interest include but are not limited to alcohol, opioids, nicotine and polysubstance use. PCORI is particularly interested in applications focusing on substance use/misuse and substance use disorders in populations with high incidence, prevalence or burden, or that experience lower access to or effectiveness of interventions.…

Topic areas: Life Sciences and Health, Public Policy and Governance, Social Sciences and Humanities.

Funding amount

This grant provides Varies in funding.

Deadline

Applications are accepted on a rolling basis; there is no single fixed deadline.

Who can apply

This opportunity is open to the following applicant types:

• Not specified by the program.

Eligibility

The program did not publish a separate eligibility statement. See the official opportunity page for the full eligibility criteria.

Agency

Addressing Substance Use PCORI Funding Announcement -- Cycle 3 2026 is administered by Patient-Centered Outcomes Research Institute (PCORI), listed via Patient-Centered Outcomes Research Institute.